Dengue Outbreak Detection Model Using Artificial Immune System: A Malaysian Case Study

Authors

  • Mohamad Farhan Mohamad Mohsin School of Computing, Universiti Utara Malaysia, Malaysia
  • Azuraliza Abu Bakar Faculty of Science & Information Technology, Universiti Kebangsaan Malaysia, Malaysia
  • Abdul Razak Hamdan Faculty of Science & Information Technology, Universiti Kebangsaan Malaysia, Malaysia
  • Mazrura Sahani Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Malaysia
  • Zainudin Mohd Ali Negeri Sembilan State Health Department, Negeri Sembilan, Malaysia

DOI:

https://doi.org/10.32890/jict2023.22.3.4

Keywords:

Aedes, artificial immune system, danger theory, dengue, outbreak

Abstract

Dengue is a virus that is spreading quickly and poses a severe threat in Malaysia. It is essential to have an accurate early detection system
that can trigger prompt response, reducing deaths and morbidity. Nevertheless, uncertainties in the dengue outbreak dataset reduce
the robustness of existing detection models, which require a training phase and thus fail to detect previously unseen outbreak patterns.
Consequently, the model fails to detect newly discovered outbreak patterns. This outcome leads to inaccurate decision-making and delays
in implementing prevention plans. Anomaly detection and other detection-based problems have already been widely implemented with
some success using danger theory (DT), a variation of the artificial immune system and a nature-inspired computer technique. Therefore,
this study employed DT to develop a novel outbreak detection model. A Malaysian dengue profile dataset was used for the experiment.
The results revealed that the proposed DT model performed better than existing methods and significantly improved dengue outbreak
detection. The findings demonstrated that the inclusion of a DT detection mechanism enhanced the dengue outbreak detection
model’s accuracy. Even without a training phase, the proposed model consistently demonstrated high sensitivity, high specificity,
high accuracy, and lower false alarm rate for distinguishing between outbreak and non-outbreak instances.

References

Ahmad, R., Suzilah, I., Wan Najdah, W. M. A., Topek, O., Mustafakamal, I., & Lee, H. L. (2018). Factors determining dengue outbreak in Malaysia. PloS One, 13(2), e0193326– e0193326. https://doi.org/10.1371/journal.pone.0193326

Aickelin, U., & Greensmith, J. (2008). Sensing danger: Innate immunology for intrusion detection. CoRR, abs/0802.4. http://arxiv.org/abs/0802.4002

Baharom, M., Ahmad, N., Hod, R., & Abdul Manaf, M. R. (2022). Dengue early warning system as outbreak prediction tool: A systematic review. Risk Management and Healthcare Policy, 15, 871–886, https://doi.org/10.2147/RMHP.S361106

Bakar, A. A., Kefli, Z., Abdullah, S., & Sahani, M. (2011, July). Predictive models for dengue outbreak using multiple rulebase classifiers. In Proceedings of the 2011 International Conference on Electrical Engineering and Informatics (pp. 1–6). https://doi.org/10.1109/ICEEI.2011.6021830

Bi, R., Timmis, J., & Tyrrell, A. (2010, July). The diagnostic dendritic cell algorithm for robotic systems. In IEEE Congress on Evolutionary Computation (pp. 1–8). https://doi.org/10.1109/ CEC.2010.5586499

CDC. (2021). Dengue - Statistics and maps. Centers for Disease Control and Prevention. https://www.cdc.gov/dengue/statistics-Journal of ICT, 22, No. 3 (July) 2023, pp: 399-maps/index.html?CDC_AA_refVal=https%3A%2F%2Fwww. cdc.gov%2Fdengue%2Fepidemiology%2Findex.html

Cheong, Y. L., Burkart, K., Leitão, P. J., & Lakes, T. (2013). Assessing weather effects on dengue disease in Malaysia. International Journal of Environmental Research and Public Health, 10(12), 6319–6334. https://doi.org/10.3390/ijerph10126319

González-Patiño, D., Villuendas-Rey, Y., Argüelles-Cruz, A. J., Camacho-Nieto, O., & Yáñez-Márquez, C. (2020). AISAC: An artificial immune system for associative classification applied to breast cancer detection. Applied Sciences, 10(2), 515. MDPI AG. http://dx.doi.org/10.3390/app10020515

Greensmith, J., Twycross, J., & Aickelin, U. (2006, July). Dendritic cells for anomaly detection. In 2006 IEEE International Conference on Evolutionary Computation (pp. 664–671). https://doi.org/10.1109/CEC.2006.1688374

Greensmith, J., Aickelin, U., & Cayzer, S. (2008). Detecting danger: The dendritic cell algorithm. In Schuster, A. (Ed.), Robust intelligent systems (pp. 89–112). Springer. https://doi.org/10.1007/978-1-84800-261-6_5

Greensmith, J., & Aickelin, U. (2008, August). The deterministic dendritic cell algorithm BT - Artificial immune systems. In International Conference on Artificial Immune Systems (pp. 291–302). Springer Berlin Heidelberg.

Huang, R., Tawfik, H., & Nagar, A. K. (2009, December). Artificial dendritic cells algorithm for online break-in fraud detection. In 2009 Second International Conference on Developments in ESystems Engineering (pp. 181–189). https://doi.org/10.1109/ DeSE.2009.59

Husin, N. A., Mustapha, N., Sulaiman, M. N., & Yaakob, R. (2012, September). A hybrid model using genetic algorithm and neural network for predicting dengue outbreak. In 2012 4th Conference on Data Mining and Optimization (DMO) (pp. 23–27). https://doi.org/10.1109/DMO.2012.6329793

Lei, D., Yu, F., & Zhenghua, Y. (2013). Survey of DCA for abnormal detection. Journal of Software, 8, 2087–2094.

Loh, F. F. (2016, January 12). Numbers of dengue cases to rise further when El Nino hits. The Star. https://www.thestar.com.my/ news/nation/2016/01/12/a-week-into-2016-1000-extra-cases-numbers-to-rise-further-when-el-nino-hits

Long, Z. A. (2012). Teknik perlombongan corak data terpencil-kerap bagi pengesanan wabak dalam pengawasan kesihatan awam [PhD dissertation, Universiti Kebangsaan Malaysia]. Journal of ICT, 22, No. 3 (July) 2023, pp: 399-

Long, Z. A., Bakar, A. A., Hamdan, A. R., & Sahani, M. (2010, November). Multiple attribute frequent mining-based for dengue outbreak BT. In Advanced Data Mining and Applications: 6th International Conference, ADMA 2010 (pp. 489–496). Springer Berlin Heidelberg.

Masmas, B. A., & Mohamed, A. (2021). Knowledge-based decision support system for emergency management: The pandemic framework. Journal of Information and Communication Technology, 20(4), 599–628. https://doi.org/10.32890/ jict2021.20.4.6

Mousavi, M., Bakar, A. A., Zainudin, A. S., Long, Z. A., & Sahani, M. (2013). Negative selection algorithm for dengue outbreak detection. Turkish Journal of Electrical Engineering & Computer Sciences, 1(1), 2346–2356.

Matzinger, P. (1994). Tolerance, danger, and the extended family. Annual Review of Immunology, 12, 991–1045. https://doi.org/10.1146/annurev.iy.12.040194.005015

Mohd Diah, I., & Aziz, N. (2022). The comparison between standardized mortality ratio, poisson-gamma and stochastic sic model for pneumonia disease mapping in Malaysia. Journal of Information and Communication Technology, 21(4), 549–570. https://doi.org/10.32890/jict2022.21.4.4

Mudin, R. N. (2015). Dengue incidence and the prevention and control program in Malaysia. IIUM Medical Journal Malaysia, 14(1). https://doi.org/10.31436/imjm.v14i1.447

Ong, S.-Q., Ahmad, H., & Mohd Ngesom, A. M. (2021). Implications of the COVID-19 lockdown on dengue transmission in Malaysia. Infectious Disease Reports, 13(1), 148–160. https://doi.org/10.3390/idr13010016

Periasamy, K., Periasamy, S., Velayutham, S., Zhang, Z., Ahmed, S. T., & Jayapalan, A. (2022). A proactive model to predict osteoporosis: An artificial immune system approach. Expert Systems, 39(4), e12708.

Pham, D., Aziz, T., Kohan, A., Nellis, S., Abd. Jamil, J., Khoo, J., Lukose, D., Bakar, S. A., & Sattar, A. (2015, October). An efficient method to predict dengue outbreaks in Kuala Lumpur. In Proceeding of the 3rd International Conference on Artificial Intelligence and Computer Science (AICS2015), Penang, Malaysia (pp. 169–178).

Salim, N. A. M., Wah, Y. B., Reeves, C., Smith, M., Yaacob, W. F. W., Mudin, R. N., Dapari, R., Sapri, N. N. F. F., & Haque, U. (2021). Prediction of dengue outbreak in Selangor Malaysia Journal of ICT, 22, No. 3 (July) 2023, pp: 399-using machine learning techniques. Scientific Reports, 11(1), 939. https://doi.org/10.1038/s41598-020-79193-2

Seng, S. B., Chong, A. K., & Moore, A. (2005, November). Geostatistical modelling, analysis and mapping of epidemiology of dengue fever in Johor State, Malaysia. In 17th Annual Colloquium of the Spatial Information Research Centre (SIRC 2005: A Spatio-temporal Workshop) (pp. 109–123).

Suppiah, J., Ching, S.-M., Amin-Nordin, S., Mat-Nor, L.-A., Ahmad-Najimudin, N.-A., Low, G. K.-K., Abdul-Wahid, M.-Z., Thayan, R., & Chee, H.-Y. (2018). Clinical manifestations of dengue in relation to dengue serotype and genotype in Malaysia: A retrospective observational study. PLoS Neglected Tropical Diseases, 12(9), e0006817. https://doi.org/10.1371/ journal.pntd.0006817

Tarmizi, N. D. A., Jamaluddin, F., Bakar, A. A., Othman, Z. A., Zainudin, S., & Hamdan, A. R. (2013). Malaysia dengue outbreak detection using data mining models. Journal of Next Generation Information Technology (JNIT), 4, 96-107.

Timmis, J., Hone, A., Stibor, T., & Clark, E. (2008). Theoretical advances in artificial immune systems, Theoretical Computer Science, 403(1), 11–32.

Toshniwal, A., Mahesh, K., & Jayashree, R. (2020, October). Overview of anomaly detection techniques in machine learning. In 2020 Fourth International Conference on I-SMAC (IoT in Social, Mobile, Analytics and Cloud) (I-SMAC) (pp. 808–815). https://doi.org/10.1109/I-SMAC49090.2020.9243329

WHO. (2021). Dengue and severe dengue. World Health Organisation. https://www.who.int/news-room/fact-sheets/detail/dengue- and-severe-dengue

Yan, W., Lee, G., Fu, X., & T. H. (2008, July). Detect climatic factors contributing to dengue outbreak based on wavelet, support vector machines and genetic algorithm. In Proceeding of the World Congress on Engineering 2008 (Vol. 1, pp. 2–4).

Yan, S., Li, T., & Zheng, H. (2021, January). Prediction model of sleep membership in drugstores based on immune danger theory. In 2021 IEEE International Conference on Power Electronics, Computer Applications (ICPECA), Shenyang, China (pp. 631-635). https://doi.org/10.1109/ICPECA51329.2021.9362558

Yang, W., Li, Z., Lan, Y., Wang, J., Ma, J., Jin, L., Sun, Q., Lv, W., Lai, S., Liao, Y., & Hu, W. (2011). A nationwide web-based automated system for outbreak early detection and rapid Journal of ICT, 22, No. 3 (July) 2023, pp: 399-response in China. Western Pacific Surveillance and Response Journal (WPSAR), 2(1), 10–15. https://doi.org/10.5365/ WPSAR.2010.1.1.009

Yavari Nejad, F., & Varathan, K. D. (2021). Identification of significant climatic risk factors and machine learning models in dengue outbreak prediction. BMC Medical Informatics and Decision Making, 21(1), 141. https://doi.org/10.1186/s12911-021-01493-y

Zhang, H., Li, Z., Lai, S., Clements, A. C. A., Wang, L., Yin, W., Zhou, H., Yu, H., Hu, W., & Yang, W. (2014). Evaluation of the performance of a dengue outbreak detection tool for China. PloS One, 9(8), e106144–e106144. https://doi.org/10.1371/ journal.pone.0106144

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Published

24-07-2023

How to Cite

Mohamad Mohsin, M. F., Abu Bakar, A., Hamdan, A. R., Sahani, M., & Mohd Ali, Z. (2023). Dengue Outbreak Detection Model Using Artificial Immune System: A Malaysian Case Study. Journal of Information and Communication Technology, 22(3), 399-419. https://doi.org/10.32890/jict2023.22.3.4

Research impact

Harvested 2026-09-06
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Identifiers DOI 10.32890/jict2023.22.3.4 OpenAlex W4386103448 Scopus 85168597535

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